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Specifically, the progressive loss of behavioral control, manifested by persistent overconsumption despite adverse consequences, mirrors the sustained positive energy balance that underlies and perpetuates weight gain (O'Connor and Kenny, 2022

Clinically, PCOS patients exhibit reduced gut microbial -diversity, an elevated Bacteroidetes-to-Firmicutes ratio, and decreased abundance of beneficial bacteria such as Akkermansia muciniphila

GLP-1 agonists act on the metabolism upstream of the liver manifestations, but this does not mean they solve all problems, such as fibrotic liver injury

Food consumed passes through the digestive tract in the usual order, allowing it to be fully absorbed in the body

Over the next year, the placebo group regained 14% of their weight, while the Zepbound group lost an additional 5.5%

McGraw-Hill / Lange Meier JJ (2012): GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus