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PIONEER 2 and 10 were open-label studies, deemed high risk for performance bias, while the others employed a double-blind design

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As our data span over 17 years, for each feature, after data processing, we examined the data range and distribution in each year, to ensure that the data could be combined

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Clinical Studies In relatively short-term clinical trials, adult obese subjects instructed in dietary management and treated with anorectic drugs lost more weight on the average than those treated with placebo and diet
