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Although tachyphylaxis to this effect may occur with long-acting GLP-1 receptor agonists, GLP-1-associated slowing of gastric emptying does not appear to be responsible for the nausea and vomiting often reported with the use of GLP-1 receptor agonist treatment

The investigators conducted emulation target trials, a statistical approach that mimics a randomized clinical trial

However, the arsenal of therapeutic options, extended in recent years to SGLT2is, GLP-1RAs, and DPP-4is, has overturned the approach to the management of T2D, moving from a conventional, simplistic, glucose-centered point of view to a holistic, cardiorenalmetabolic, and multi-target organ-protective perspective

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In contrast, products from SemaSpace, BiotechPeptides, and USChemLabs scored considerably lower, with 9, 8, and 8 points, respectively

The SURMOUNT-5 trial, published in 2025 in the New England Journal of Medicine, directly compared tirzepatide with semaglutide