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McIntyre RS, Soczynska JK, Konarski JZ, Kennedy SH

From diabetes to degenerative diseases: the multifaceted action of metformin

When you combine GLP-1 and GIP receptor activation, the result is more potent appetite suppression, greater improvements in insulin sensitivity, and significantly more weight loss than either receptor activation alone

The implications of this when using incretins for weight loss are somewhat different compared to use for managing hormones in type 1 diabetes

Exendin-4 has been shown to reduce advanced glycation end product (AGE)-induced interleukin (IL)-6 and TNF- production, the expression of receptor for AGE (RAGE), and cell death in mesangial cells (Chang et al., 2017)

The downsides of GLP-1s can be summed up in one message: You dont know what youre getting