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Brusegan A, McKay G, Llano A (2020) Pramlintide

So a careful, individualized approach is necessary for a smooth and safe transition

Clinical Takeaways As the prevalence of obesity, insulin resistance, metabolic syndrome and associated health complications continue to rise, targeting GLP-1 activity has emerged as a promising strategy in improving cardiometabolic health and encouraging sustainable weight loss

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A 2025 mechanistic review published in The Journal of Clinical Endocrinology and Metabolism showed that tirzepatide, which activates the GIP receptor, showed less BMD loss than expected for the weight loss achieved