do oral semaglutide pills work FDA Approves as the First Oral GLP-1 Pill Optimal dosing and administration instructions
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232.Gough SC, Bode B, Woo V, et al

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Semaglutide trial shows promise for schizophrenia, prediabetes, and obesity Summary of the HISTORI Randomized Clinical Trial The HISTORI trial, published in *JAMA Psychiatry* on September 3, 2025 (doi:10.1001/jamapsychiatry.2025.2332), is a multicenter, double-blind, placebo-controlled randomized clinical trial evaluating the efficacy and safety of once-weekly subcutaneous semaglutide (a glucagon-like peptide-1 receptor agonist) as an adjunct to second-generation antipsychotic treatment in adults with schizophrenia spectrum disorders, prediabetes (HbA1c 5.7%-6.4%), and overweight/obesity (BMI 27 kg/m)

Saxenda is licensed for weight loss and is an injectable pen which is taken daily

while Mounjaro should be refrigerated, it can be kept at room temperature briefly before use

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