how long have glp 1 been around Glucagon-like peptide-1 receptor: mechanisms and advances in therapy The Buzz Around GLP-1 Agonists
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One specific consideration for tirzepatide users: because the once-at-room-temperature-can't-return-to-fridge rule means the 21-day clock runs from first removal from refrigeration, consider timing your pen removal carefully around your trip

Luna-Marco C, de Maraon AM, Hermo-Argibay A, et al
Back Bell, GI, Sangez-Pescador, R, Laybourn, PJ, Najarian RC (1983) 'Exon duplication and divergence in the human preproglucagon gene', Nature , 304, 368-71

Probiotic supplements can also help support healthy gut balance

Salacia Reticulata Improves Serum Lipid Profiles and Glycemic Control in Patients With Prediabetes and Mild to Moderate Hyperlipidemia: A Double-Blind, Placebo-Controlled, Randomized Trial

However, coverage varies widely between insurance plans