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We uncover known pathways, such as DAF-16 in mediating the extended lifespan of the glp-1(-) and fem-3(-) mutants, and also reveal additional insights, including a possible central role of sphingolipid metabolism in the longevity of self-sterile mutants and that masculinized mutants may serve as a useful genetic model for further investigation of mating-induced metabolic reprogramming and premature death (Fig

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(2) Gastric emptying delaypramlintide slows gastric emptying by 2030%, spreading glucose absorption over a longer period and flattening the postprandial glucose curve