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Keywords: GLP-1 receptor agonists, type 2 diabetes mellitus, gastrointestinal adverse events, Bayesian network meta-analysis, nausea, vomiting, diarrhea 1 Introduction According to the International Diabetes Federation, the global population with diabetes reached 537 million by 2021, with 90% of cases attributed to type 2 diabetes (T2DM) (Ahmad et al., 2022)

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Ca 2+ levels are regulated (38) to balance disorders of cardiac calcium metabolism, inhibiting cardiac hypertrophy (39) and decreasing heart failure risk

Genetics also play a significant role in determining where stubborn fat persists

Only one case of liver damage has been reported from semaglutide as per the American Journal of Gastroenterology, which is exceptionally low

Retatrutide interactions that may occur include insulin, oral diabetes medications, and medicines that influence digestion