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While many interventions for AD/ADRD have focused on midlife and late-life deficits, a precision brain health approach to AD/ADRD prevention should consider opportunities for personalized interventions implemented at earlier ages as part of a life-course approach to brain health optimization and resilience

This includes 39% who report currently taking a GLP-1 and 10% who have taken one but stopped

GLP-1 receptor agonists like semaglutide (Ozempic), liraglutide (Victoza), and tirzepatide (Mounjaro) help by increasing insulin secretion in response to meals, thereby lowering blood sugar levels

Serum was collected at 10 time points: baseline, 2.5 h, 6 h, 11 h, 22 h and 24 h, Week 2 at baseline and 2.5 h post-dose, Week 12 at baseline and 2.5 h post-dose

The emmeans R package (version 1.7.1-7) was used for the estimation of EMMs and contrasts

Nausea, vomiting, constipation, diarrhea, bloating, gas, gastritis, and fatigue typically most pronounced during initiation and dose escalation