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Conclusion During the UKPDS (UK Prospective Diabetes Study) era, we learned that the natural history of T2D involved a progressive and irreversible deterioration of -cell function leading to its complete exhaustion and the subsequent need for intensive insulin treatment

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119.Ja'arah D, Al Zoubi MS, Abdelhady G, Rabi F, Tambuwala MM
The publication appeared in the New England Journal of Medicine, the most prestigious medical journal in the world

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