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GLP-1 medications address the underlying metabolic factors that drive weight gain, so emphasizing metabolic health rather than appearance-based goals often resonates better with physicians and strengthens the clinical rationale for treatment

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However, the optic nerve may be uniquely vulnerable to changes in perfusion, autoregulation, metabolic status and local anatomic susceptibility, and favorable systemic vascular effects may not necessarily translate into reduced optic nerve ischemic risk. Beyond their cardiovascular benefits, GLP-1 agents may also influence ocular microvascular physiology

Unsupervised graph-based clustering was performed on the first 20 principal components

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