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doi: 10.1080/01616412.2016.1145914 198 PanagakiTMichaelMHolscherC
From 2018 to 2023, GLP-1RA prescriptions increased by 300%, owing to its efficacy, safety, and simplicity
Recent Developments: 2025: Eli Lilly received FDA approval for tirzepatide (Zepbound) as a treatment for moderate-to-severe obstructive sleep apnea in adults with obesity the first pharmacotherapy approved for this indication expanding tirzepatide's approved uses beyond metabolic conditions into a respiratory indication affecting over 30 million Americans and supported by SURMOUNT-OSA trial data showing 63% reduction in apnea-hypopnea index
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The above studies show that GLP-1 and GLP-1RAs can enhance BAT function or promote WAT browning through the center
PIONEER 9 and PIONEER 10 are trials that enrolled Japanese participants with T2DM to meet regulatory requirements in Japan
