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Baseline cardiovascular assessment should include detailed history of prior cardiovascular events, current symptoms, blood pressure measurement, lipid profile, renal function assessment, and calculation of 10-year atherosclerotic cardiovascular disease (ASCVD) risk using validated tools such as the Pooled Cohort Equations

Exercise may help: maintain metabolic rate preserve muscle mass improve insulin sensitivity reduce stress levels support consistent energy levels Both resistance training and cardiovascular activity can support long-term weight maintenance

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Tirzepatide's weight loss mechanismappetite suppression, improved insulin sensitivity, and slowed gastric emptyingoperates independently of gallbladder function

The American Journal of Gastroenterology, 108(2), 270276

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