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Abbreviations AICAR: Aminoimidazole carboxamide ribonucleotide AMPK: AMP-activated protein kinase DPP-4: Dipeptidyl peptidase-4 GIP: Gastric inhibitory polypeptide GLP-1: Glucagon-like peptide 1 GLP1R: GLP-1 receptor HBSS: Hanks balanced salt solution LKB1: Liver kinase B1 PPAR: Peroxisome proliferator-activated receptor References Nathan DM, Buse JB, Davidson MB et al (2009) Management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy