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Reductions in liver enzymes (ALT, AST) and improvements in non-invasive fibrosis markers were also observed

The increase in vision loss claims comes after emerging dataincluding a June 2025 JAMA Ophthalmology studylinked semaglutide use to significantly higher rates of NAION

Results from a phase 1 trial have supported further clinical evaluation with a dose-dependent WL up to 14.5% with AMG133 compared to 1.5% with placebo by day 85 [59]
Semaglutide breakthrough: new hope for heart health in the fight against obesity Over 17,000 patients took part in the SELECT clinical trials which found that semaglutide (Wegovy / Ozempic) resulted in a 20% reduction in major cardiovascular events

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