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Dulaglutide is a long-acting GLP-1RA used for T2DM with demonstrated cardiovascular benefits.[10] Liraglutide, another long-acting GLP-1RA, is used for T2DM and obesity management and is under investigation for Alzheimers disease and metabolic-associated hepatic steatosis.[4] Lixisenatide, a short-acting GLP-1RA, shows comparable efficacy to exenatide and liraglutide for T2DM management, and is now combined with insulin glargine.[23] Semaglutide, available in injectable and oral forms, has demonstrated benefits in promoting weight loss, reducing risk of cardiovascular events, and slowing progression of diabetic CKD.[24] Finally, tirzepatide is a dual agonist for receptors of GLP and glucose-dependent insulinotropic polypeptide (GIP), a hormone released from the intestines in response to macronutrients.[25] These two mechanisms of action have synergistic glucose-lowering and weight loss effects with lower side effect rates than other GLP-1RAs.[25] Tirzepatide has also been shown to result in blood pressure reduction, obstructive sleep apnea control, and improved cholesterol in T2DM patients.[5] Table

However, if it frequently occurs or you have additional symptoms, talking to a provider can help you get to the root cause, including malabsorption issues

10.1093/ajcn/nqy310 [DOI] [PubMed] [Google Scholar] 101.Nor Hanipah Z, Punchai S, Birriel TJ, Lansang MC, Kashyap SR, Brethauer SA, et al

First, alcohol can worsen the GI side effects of tirzepatide, so avoiding alcohol for 24 to 48 hours after injection is advisable

These benefits are driven in large part by type 2 diabetes outcomes, where cost offsets from fewer hospitalizations and complications outweigh drug costs

He found solace and inspiration on TikTok, opening the door to a cheaper drug that he believes in