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Tirzepatide (Zepbound, Mounjaro) Tirzepatide is the newest entrant in this category and represents a significant advance because it activates both GLP-1 and GIP receptors

doi: 10.1016/j.cpcardiol.2024.102489, PMID: [DOI] [PubMed] [Google Scholar] 33

[6] [7] These proposed complementary mechanisms are supported by early-phase human data, though the precise contribution of each receptor pathway in clinical practice has not yet been fully established

The GLP-1 sequence is highly conserved among mammals and is released in its active form (7-36) in response to food intake

Clinical trials show average weight loss of 15% body weight over 68 weeks with semaglutide 2.4 mg weekly, though individual results vary