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Previous serious hypersensitivity reaction: anaphylaxis, angioedema or severe allergic responses to a specific GLP 1 medication mean you shouldnt be re-exposed to that agent

While its full safety profile is still being established in Phase 3 trials, initial data from Phase 2 trials suggest that retatrutide is generally well-tolerated

Krhus ML, Ellegaard AM, Winther-Jensen M, et al

Adipose tissue remodeling ERR-dependent programs in adipose tissue intersect with thermogenesis, lipolysis, and adipocyte mitochondrial function

S.Van WittenbergheN.EricssonM.GriffinG

The NCE period for tirzepatide runs through May 13, 2027, which means generic companies may not file an ANDA seeking approval for a generic version of Mounjaro or Zepbound until May 13, 2026, with patent infringement lawsuits expected to occur in the following months