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This may be caused by electrolyte imbalances, dehydration, blood sugar fluctuations, stress, fatigue, and medication interactions

Some are also approved for a liver condition known as metabolic dysfunction-associated steatohepatitis (MASH)

The same trial's main insulin-sensitivity endpoint was null for the group as a whole, with benefits concentrated in subgroups, so the honest reading is that the GLP-1 finding is real but the overall metabolic picture is mixed

10.1038/nrendo.2015.128 [DOI] [PubMed] [Google Scholar] 5

The risk of depression, anxiety, and suicidal behavior in patients with obesity on glucagon-like peptide-1 receptor agonist therapy

Months prior, the FDA had also taken tirzepatide, a GLP-1 and GIP dual receptor and the active ingredient in weight-loss drug Zepbound and type 2 diabetes drug Mounjaro, off a similar shortage list