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In line with this, an increased potential to synthesise BCAAs and decreased microbial BCAA uptake and catabolism have been described in the GM of insulin-resistant individuals with normoglycaemia [18]

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doi: 10.1210/jc.2011-2407 209 AlvesCBatel-MarquesFMacedoAF

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At 26 weeks, PIONEER 12 was relatively short compared with most of the global PIONEER trials, except for PIONEER 1 and 5, and was considerably shorter than the 78 week PIONEER 3 trial that it mirrors

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