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These weight losses are even more pronounced in people who are obese but do not have diabetes (Figure 5)

Racial/ethnic disparities in diabetes quality of care: the role of healthcare access and socioeconomic status

From a broader immunologic perspective, Karacabeyli and Lacaille 1 note that GLP-1 RAs may influence shared inflammatory pathways involved in immune-mediated inflammatory diseases (IMIDs), including psoriasis and inflammatory arthritis

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For example, someone who weighs 250 pounds burns more calories at rest than someone who weighs 200 pounds

When patients lose 1520% of body weight over 36 months, their skeletal system undergoes significant biomechanical rebalancing