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The science: GLP-1 medications are glucose-dependentthey only stimulate insulin when blood sugar is elevated HOWEVER, hypoglycemia risk increases significantly when combined with: Sulfonylureas (glimepiride, glyburide) Insulin Extreme caloric restriction Low blood sugar can present with cold, clammy sensations, sweating, and shaking Research findings: One study showed 9.2% hypoglycemia rate when liraglutide was combined with glimepiride vs 2.6% with placebo In monotherapy, GLP-1s show similar hypoglycemia rates to placebo in most studies The median time to hypoglycemia onset after starting GLP-1s is 5 days in reported cases Why you feel cold: Hypoglycemia triggers a stress response including vasoconstriction and can directly cause cold sensations

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Eso significa que pueden venderse legalmente, pero no han pasado por la misma evaluacin de seguridad y eficacia que los medicamentos autorizados