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Digestive benefits like reduced bloating and improved regularity also receive frequent praise

Across age groups, current GLP-1 use is highest among adults ages 50-64 (22%)

These are fundamentally different drug classes with distinct mechanisms, side effect profiles, and evidence bases

, liraglutide improved measures of cardiac performance through an AMPK-dependent mechanism (Noyan-Ashraf et al

Effects of resmetirom on metabolic-dysfunction associated steatohepatitis in patients with weight loss and/or diabetes taking glucagon-like peptide-1 receptor agonists and other diabetes therapies: a secondary analysis of the MAESTRO-NASH trial

For weight management in patients without diabetes, the situation is more nuanced but current evidence suggests that obesity should also be treated as a chronic condition requiring ongoing management