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Patients with high-sensitivity genotypes often feel appetite suppression within days and achieve weight loss by week 12, while others may require 46 weeks of consistent dosing

The most common side effects are gastrointestinal, with nausea occurring in 15-44% of patients, followed by vomiting, diarrhea, constipation, and abdominal discomfort

Patients with a history of pituitary tumors, severe carpal tunnel syndrome, uncontrolled diabetes, or malignancy should avoid HGH

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