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The 2015 American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) clinical practice guidelines also note the importance of weight management in patients with type 2 diabetes and recommend the use of antihyperglycemic agents that are associated with weight loss or at least have a neutral effect on body weight (23)

Onishi, Y., Oura, T., Matsui, A., Matsuura, J

4 By contrast, a meta-analysis of bariatric surgery studies found that surgical intervention produces sustained weight loss and has large positive effects both on quality-of-life scores and cardiovascular risk factors in patients under 18 with obesity

Treatment requires specialist prescribing, regular monitoring for adverse effects including pancreatitis, and integration with lifestyle modifications

It means a 0.25mg weekly injection delivers more systemic semaglutide than a 1mg daily sublingual dose in many cases