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Main text Modern GLP-1 receptor agonists and co-agonists (GLP-1 medicines) such as liraglutide, dulaglutide semaglutide, and the GLP-1R/glucose dependent insulinotropic polypeptide receptor (GIPR) co-agonist tirzepatide, were initially developed for the treatment of type 2 diabetes (T2D) due to their actions to increase insulin and decrease glucagon secretion and slow gastric emptying through effects on the pancreas and brain

Choose your medication (compounded semaglutide or Zepbound)

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It is worth mentioning that a groundbreaking double-blind, placebo-controlled phase three trial study was recently published (Harrison et al., 2023), that pointed out the safety and liver specific benefits of resmetirom on NAFLD, which is the first drug expected to be approved for the disease

Frequently Asked Questions ( FAQ ) Uncovering the Answers to Common Health Concerns

The data: Most patients who got prescribed a GLP-1 for the first time in 2023 or 2024 ended up discontinuing treatment before long, and many never filled their prescription at all, according to a November 2025 IQVIA analysis of GLP-1 prescription claims