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Eli Lilly noted that discontinuation rates were highly correlated with baseline BMI, with participants who had lower baseline BMI more likely to discontinue due to excessive weight loss
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Energy deficiency may enhance intracortical remodeling and reduce periosteal bone apposition, leading to a net loss of cortical thickness and strength
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In randomized trials among people with Type 2 diabetes, the drugs achieved HbA1c reduction of at least an absolute 2 percentage points which led to their FDA approvals (For semaglutide in January 2020, and for tirzepatide in May 2022)
