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Any abrupt, intense abdominal pain on GLP1s warrants urgent evaluation rather than waiting to see if it passes. The GI falloutespecially prolonged vomiting and diarrheacan cause dehydration, low blood pressure, dizziness, and prerenal acute kidney injury

Along this line, a recent large case-control study from 2024 including 162,253 obese patients treated with GLP-1 RAs and a matched group of untreated patients found an association between GLP-1 RAs and increased risk of depression, anxiety and suicidal behavior [10]

These results support the potential role of GLP-1s in metabolic care, though each patients situation is unique

No GP or specialist in the UK would be in a position to supervise or endorse the combined use of these two agents outside of a formal clinical trial, given the complete absence of safety and efficacy data for this combination

Those of us whose tax dollars supported his curiosity are the beneficiaries

The weight loss pill also significantly improved heart health markers like cholesterol and blood pressure