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Most patients benefit from continued therapy, even at lower maintenance doses, to sustain weight loss and prevent metabolic creep back toward baseline

Glycosuria reduces blood glucose levels and contributes to caloric loss [3], but there also seems to be a direct action of SGLT2i on adipose tissue metabolism, as evidenced, for example, by their impact on EAT [9].Based on these premises, this review aims to examine and clarify the effects of SGLT2i on adipose tissue, focusing on their impact on metabolic health and evaluating how they might transform treatment strategies for type 2 diabetes and metabolic diseases

Luis-Emilio Garca, who is an associate vice president at Eli Lilly, said in a release