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Description
Adults with biopsy-proven MASH and fibrosis stage F1F2F3, with or without type 2 diabetes, and with MRI-PDFF 8% at screening are randomised 1:1:1:1 to efocipegtrutide 2, 4, and 6 mg once-weekly subcutaneously or placebo for 52 weeks (estimated enrolment: N = 240)
Microdosing uses lower-than-standard doses titrated to individual response
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Wegovy is specifically approved for adults with obesity or those who are overweight with at least one related health condition, such as hypertension, diabetes , or high cholesterol

As people eat less and lose weight (left side), they may develop nutrient deficiencies such as low vitamin D, iron-deficiency anemia, or even muscle loss (middle)

Ultimately, understanding the existing forces that occur in a weight-reduced state may help to understand what may drive weight regain [224,225]