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History of pancreatitis Severe gastrointestinal disease Gallbladder disease or a history of cholelithiasis Pregnancy or breastfeeding Concomitant use of insulin or insulin secretagogues (e.g., sulphonylureas), which may increase hypoglycaemia risk Retatrutide, like other incretin-class medicines, may slow gastric emptying, which can affect the absorption of oral medicines taken at the same time

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However, the nature of that growth is changing

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Current evidence suggests semaglutide does not significantly affect male fertility

However, further long-term studies are necessary to evaluate its sustained efficacy, safety and broader metabolic outcomes