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Severe Nutritional Deficiencies If your leg pain is accompanied by extreme weakness, numbness, or a pins and needles sensation, you may have a significant vitamin deficiency (such as Vitamin B12) or a neurological issue

Likewise, in an icv-A-injected AD rat model, exendin-4 improved memory function, lowered A levels, and restored both acetylcholine levels and mitochondrial function, potentially through the PI3K/Akt signaling pathway [100]

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