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Theoretical models indicate that GLP-1RAs and amylin analogs may function synergistically to promote weight loss [80]
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They work through related but distinct mechanisms to regulate appetite, blood sugar, and metabolism
The effect of GLP-1R agonists liraglutide and exendin-4 was examined in vitro on LOVO, CA-77, MCF-7, MDA-MB-231, KPL-1, MB-468, 4TI, BT483, ZR751, LNCap, PC3, ALVA-41, DU145, LNCap, PANC-1, MiaPaCa-2, PANC, CT26, SKOV3, OVCAR3, OVCAR4, A2780, and ES-2 cell lines that are expressed in several cancers including colorectal, pancreatic, thyroid, breast, prostate, ovarian, and colon (Table 1)
After even 3 days of regular high fiber dietary consumption, studies have shown that GLP-1 levels can go up by as much as 56%
doi: 10.12688/f1000research.20602.1 [DOI] [PMC free article] [PubMed] [Google Scholar] 96
