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Effect of acute DPP-4 inhibition on glucose tolerance Mice were fasted for 45 h prior to OGTTs

[2] While a causal link between GLP-1 agonists and pancreatitis has not been established in large cardiovascular outcomes trials (SELECT, N=17,604, found no significant difference in pancreatitis rates between semaglutide 2.4 mg and placebo at 34 months follow-up) [7], the label contraindication remains because individual case series continue to report acute flares in patients with prior disease

They mimic the effects of the GLP-1 hormone, which helps regulate appetite, digestion, and insulin release from the pancreas

The drug was also found to reduce the risk of kidney failure
