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GLP-1 may also inhibit ANG II action at post-receptor level

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All of the data here are observational data and not experimental, Gerstein said

Contemporary reviews focusing on GLP-1 receptor agonists consistently report that reductions in lean mass, comprising skeletal muscle as well as other fat-free components such as body water and organ tissue, accompany pharmacologically induced weight loss, although the relative contribution varies based on baseline adiposity, age, metabolic health, and body composition assessment modality [6]