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First, as a result of the nature of study design, although associations can be directly assessed, causality requires additional assumptions that the study design attempts to address but may not fully meet

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The SELECT safety analysis found breast cancer rates were marginally lower on semaglutide than placebo, and a 2025 meta-analysis of 50 randomised GLP-1 trials found no increased breast cancer risk

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This often leads to: Slower metabolism Increased belly fat Insulin resistance Stronger hunger signals These changes contribute to hormonal weight gain Chicago women frequently experience, even when lifestyle habits havent changed

Adems, se han desarrollado nuevos agonistas duales y triagonistas sobre los receptores GLP-1, GIP y glucagn, como cotadutida, survodutida, pemvidutida y retatrutida, que muestran resultados prometedores en EHMET, aunque sus mecanismos an no se comprenden completamente1719