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RETA induced immune reprogramming systemically and in the tumor microenvironment with durable anti-tumor immunity evidenced by elevated circulating IL-6, increased antigen presenting cells, reduced immunosuppressive cells, and activation of pro-inflammatory pathways

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Methods This narrative review is based on a comprehensive analysis of the supplied literature set, prioritizing high-level evidence from systematic reviews, meta-analyses, clinical guidelines, and key original studies published between 2021 and 2025