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A pilot study has indicated that metformin may enhance feelings of satiety and decrease food-related anxiety in certain individuals with PWS, potentially through the mechanism of improved insulin sensitivity [39]

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2023;136(12):e2334

Discontinuations of one or two years without resuming GLP-1 use resulted in a 14% or 22% increased risk of cardiovascular events, respectively, compared to staying on the drugs

A multicenter phase IIb RCT in NASH with fibrosis stages 1-3 demonstrated the efficacy of resmetirom in reducing hepatic steatosis at 12 and 36 weeks compared with placebo