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Current studies are still largely in the preclinical or early clinical phases, and larger trials involving human subjects are necessary to confirm the safety and efficacy of these drugs for addiction treatment

Bethel MA, Diaz R, Castellana N, Bhattacharya I, Gerstein HC, Lakshmanan MC

Fifth, in some studies, hazard ratios were derived from time-to-event data or calculated from secondary endpoints, which may have introduced variability in effect estimates