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What makes this convergence striking: 23andMe used bottom-up population genetics (GWAS, n=27,885) VincoPath used top-down proteome interaction mapping Both independently point to GLP-1R signal strength as the rate-limiting variable Neither alone is sufficient genotype determines receptor density, proteome determines signaling threshold For the Alzheimer's field specifically: EVOKE enrolled 3,808 patients without genetic or proteomic stratification

This review summarises recent advances in the understanding of diabetic gastroparesis, with an emphasis on the current therapies that influence GE, and the bidirectional relationship between glycaemic control and GE.

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Despite advances in immunosuppressive treatments, maintaining functional beta cells to prevent insulitis progression and hyperglycaemia remains a challenge