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A critical analysis of recent literature highlights the importance of integrative and cautious approaches that account for the developmental plasticity of the pediatric organism and the possible pleiotropic effects of early pharmacological intervention.

GLP-1 receptor agonists used for the treatment of diabetes, have shown some neuroprotective effects in cellular and animal models of Alzheimers disease (AD) and Parkinsons disease (PD)

Despite great progress in GLP-1R structure determination, our understanding on the differences of peptide binding and signal transduction between these two receptors remains elusive

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Singh, MD, reviews the latest evidenceexamining GLP-1 therapies in relationtodiabetic retinopathy (DR), age-related macular degeneration (AMD),nonarteriticanterior ischemic optic neuropathy (NAION), and retinal vein occlusion (RVO).