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Early pioneering experimental studies demonstrated that energetic substrates such as glucose and adenosine triphosphate (ATP) are reduced during seizure activity induced by chemical agents in rodents as experimental model of acute seizure (Sacktor et al., 1966

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Due to the above-mentioned effects of TZD on glycemic, hepatic metabolism, and inflammation, treatment with dual-agonism may reduce or reverse liver damage (lobular inflammation, hepatic steatosis, liver cell damage, and fibrosis) and metabolic dysfunction (41)

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J Biol Chem (2004) 279(19):2034555