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A further nuance sharpens what the trials actually showed

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Zepbound (tirzepatide) is FDA approved for weight loss and chronic weight management in adults with obesity, as well as adults who are overweight with at least one weight-related medical condition, such as high cholesterol or high blood pressure

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Direct evidence for this relationship followed this initial discovery and included findings showing that peripheral injections of GLP-1 or the GLP-1 analog, EX4, reduce alcohol consumption in rodents (Davis et al., 2012b

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From this process, 107 papers were excluded, and 262 papers were sought for retrieval for full text

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The Plateau Problem - Why GLP-1 Therapies Stop Working (and What To Do About It) Share The Plateau Problem Why GLP-1 Therapies Stop Working (and What To Do About It) GLP-1 therapies like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have delivered remarkable results for many patientsbut for a growing number, theres a common frustration: It was working and then it wasnt. Weight loss slows

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EMA (2017)

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