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Methods We searched PubMed, Embase, Cochrane and ClinicalTrials.gov up until 27 October 2021 for randomised controlled trials with a duration of at least 12 weeks that compared once-weekly tirzepatide 5, 10 or 15 mg with placebo or other glucose-lowering drugs in adults with type 2 diabetes irrespective of their background glucose-lowering treatment

While these medications typically reduce blood pressure modestlya benefit for many patientssome individuals may experience low blood pressure (hypotension) or related symptoms like dizziness and lightheadedness

Hormonal changes during menopause primarily affect fat distribution rather than directly causing weight gain

Data Availability Statement This is a review article and does not include any original data

Mechanisms and clinical efficacy of lixisenatide for the management of type 2 diabetes

2008;3(Suppl 2):S2937