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Description
WEIGHT LOSS: In clinical trials comparing both of these peptide therapies, the following results were recorded: Because it is the newest drug in the class and has the dual receptor modality, GLP-1/GIP is considered the best medication of the two
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Sixty-three percent of the participants lost at least five percent of their body weight and about 33 percent lost at least 10 percent of their body weight

However, the GLP-1R is also involved in adipogenesis in the periphery, which may account for this discrepancy (Challa et al., Glp1r/ mice, animals with deletion of the GLP-1R in vagal afferent/efferent nerves, Phox2b-Cre Glp1r flox/flox , as well as animals with a deletion of the GLP-1R in the CNS, nestin- Cre Glp1r flox/flox , maintain a similar body weight and food intake as control mice on both chow and HFD (Sisley et al., 2014)
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Possible Side Effects Common side effects of GLP-1 medications may include: Nausea Vomiting Diarrhea Constipation Stomach pain or discomfort Decreased appetite Indigestion or gas Redness, itching, or soreness at the injection site Most side effects are mild to moderate and may improve as your body adjusts to treatment
