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and with patients who have taken GLP-1 drugs and experienced widely varying reactions.

Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule

Experimental observations also show delayed gastric emptying consistent with GLP-1 receptor signaling, although this effect may diminish over extended observation periods in some research models

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