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Third, the optimal positioning and sequencing of GLP-1-based therapies relative to resmetirom and other emerging MASH agents (e.g., lanifibranor, pegozafermin, semaglutide combination regimens) requires dedicated combination trials, of which preliminary data from the MAESTRO-NASH secondary analysis are encouraging

Research has linked GLP-1 medications to lower risks of cardiovascular disease, kidney disease, and even some neurodegenerative disorders

The MHRA Early Access to Medicines Scheme (EAMS) , which allows patients with life-threatening or seriously debilitating conditions to access promising unlicensed medicines before marketing authorisation

WeightWatchers said in its first-quarter results earlier this month that 87,000 people had subscribed to the clinic, although not all of them are taking GLP-1s

Reducing cravings: 91% of participants experienced fewer food cravings, with 86% noting reduced sugar cravings over 3 months

J Clin Invest (2017) 127(12):421727