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Description
Like pretzels
DPP-4 is a member of the serine peptidase/prolyl oligo-peptidase gene family, which includes the membrane-bound peptidases, fibroblast activation protein (FAP)/seprase
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Most of the time this reflects the positive inotropic effect (stronger contractions) rather than any dangerous rhythm abnormality
They postulate that the enhanced export of bile acids out of hepatocytes and a reduction of bile acid synthesis via inhibition of CYP7A1, which converts cholesterol to bile acids, were mediated by increased GLP-1 in DPP4-KO rats (48)
doi: 10.1016/S0021-9258(18)42531-8 [DOI] [PubMed] [Google Scholar] 84
