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The GLP-1 Case Study: Anatomy of a Crisis The trajectory of the GLP-1 receptor agonist marketspecifically semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound)offers the definitive case study for the collision of these regulatory and legal forces

Key Toxicities to Watch as a clinical pharmacist: Renal: nephrotoxicity, rising creatinine Neuro: tremors,confusion, seizures Metabolic: hypertension, QT prolongation, hyperglycemia Electrolytes: K, Mg Heres how we intervene before toxicity takes over: Slash Tacrolimus doses by ~70% when starting Posaconazole TDM every 23 days (dont wait for trouble) Monitor renal function, BP, electrolytes, glucose closely Anticipate the reverse interaction when Posaconazole is stopped tacrolimus levels crash without timely adjustment Key Insight: Pharmacists arent just dose adjusters. We are the safety net that spots silent drugdrug collisions before they harm patients

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Roy A, et al

When this tissue becomes overloaded, it develops small tears and inflammation at the point where it attaches to the heel bone

Both approaches carry similar safety profiles when used appropriately

Your provider will recommend the best option for your goals